Phase 1 Clinical Trials

267 trials are at Phase 1 in the index.

Trials (267)

A Pharmacokinetics Study to Investigate the Effect of Ketoconazole on Vemurafenib in Patients With BRAFV600 Mutation-Positive Metastatic Melanoma Phase 1 · Hoffmann-La Roche
Safety and Efficacy of iPD1 CD19 eCAR T Cells in Relapsed or Refractory B-cell Lymphoma Phase 1 · Peking University
Tipifarnib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Phase 1 · National Cancer Institute (NCI)
A Study of TAK-164 in Participants With Advanced Gastrointestinal (GI) Cancer Expressing Guanylyl Cyclase C (GCC) Phase 1 · Millennium Pharmaceuticals, Inc.
A Dose-escalation Study of Ombrabulin in Combination With Paclitaxel and Carboplatin in Patients With Advanced Solid Tumors Phase 1 · Sanofi
Mafosfamide in Treating Patients With Progressive or Refractory Meningeal Tumors Phase 1 · National Cancer Institute (NCI)
The Recombinant Humanized Anti-TIGIT Monoclonal Antibody (JS006) Monotherapy and in Combination With Toripalimab in Patients With Advanced Tumor Phase 1 · Shanghai Junshi Bioscience Co., Ltd.
Phase 1 Trial of Interleukin 12 Gene Therapy for Metastatic Pancreatic Cancer Phase 1 · Henry Ford Health System
Lattice-Based Radiotherapy and Chemo-Immunotherapy for Oral Cavity Squamous Cell Carcinoma Phase 1 · NYU Langone Health
Azacitidine to Restore Thyroid Function in Patients With Persistent or Metastatic Thyroid Cancer Phase 1 · Lucille P. Markey Cancer Center at University of Kentucky
TH1902 in Patients With Advanced Solid Tumors Phase 1 · Theratechnologies
A Study of BI 853520 in Patients With Various Types of Advanced or Metastatic Cancer Phase 1 · Boehringer Ingelheim
A Pilot Study of Intralesional Injection of Triamcinolone Acetonide for Desmoid Tumors Phase 1 · Mayo Clinic
Lenalidomide and Paclitaxel in Advanced Solid Tumors Phase 1 · Southern Europe New Drug Organization
A Phase I Trial to Assess the Effects of Food and Formulation on PK of KPT-330 in Patients With Sarcoma Phase 1 · Karyopharm Therapeutics Inc
Bevacizumab, Fluorouracil, and External-Beam Radiation Therapy in Treating Patients With Stage II or Stage III Rectal Cancer Phase 1 · National Cancer Institute (NCI)
Study to Assess the Blood Levels and Safety of AZD9291 in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment Phase 1 · AstraZeneca
Clinical Study of the Efficacy of CD19-CAR-DNT Cells in the Treatment of Relapsed/Refractory B-cell NHL Phase 1 · Second Affiliated Hospital, Zhejiang University, School of Medicine
Toripalimab Combined With Gemcitabine and Cisplatin Treating Resectable Locally Advanced HNSCC Phase 1 · Fifth Affiliated Hospital, Sun Yat-Sen University
First In Human Study of CX-801 in Advanced Solid Tumors Phase 1 · CytomX Therapeutics
Dabrafenib, Trametinib, and IMRT in Treating Patients With BRAF Mutated Anaplastic Thyroid Cancer Phase 1 · City of Hope Medical Center
Treatment of B-CLL With Human IL-2 and CD40 Ligand and Plasmid Gene Modified Autologous Tumor Cells Phase 1 · Baylor College of Medicine
Gemcitabine and Oxaliplatin (Gem-Ox) Plus Glivec in Gemcitabine-refractory Pancreatic Cancer Phase 1 · Royal Marsden NHS Foundation Trust
A Phase 1 Clinical Study to Evaluate the Effects of SHR7280 on the Pharmacokinetics of Midazolam, S-warfarin, Omeprazole, Digoxin, and Rosuvastatin in Healthy Subjects Phase 1 · Jiangsu HengRui Medicine Co., Ltd.
A Study With ABBV-155 Alone and in Combination With Taxane Therapy in Adults With Relapsed and/or Refractory Solid Tumors Phase 1 · AbbVie
A Phase I Study to Investigate the Safety, Tolerability and PK of HLX60 (Anti-GARP Monoclonal Antibody) in Subjects With Solid Tumors or Lymphoma Phase 1 · Shanghai Henlius Biotech
Study Investigating Intravesical HDAC Inhibition to Improve Response to Immuno-Oncology Agents Phase 1 · H. Lee Moffitt Cancer Center and Research Institute
Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma Phase 1 · Dartmouth-Hitchcock Medical Center
Study to Examine the Effect of HKI-272 on Rhythms of the Heart (Cardiac Repolarization) Phase 1 · Puma Biotechnology, Inc.
Pioglitazone Hydrochloride in Preventing Radiation-Induced Cognitive Dysfunction in Treating Patients With Brain Tumors Phase 1 · Wake Forest University Health Sciences
Exploratory Study on Baize DC Injection in Preventing Recurrence and Metastasis After Radical Tumor Surgery Phase 1 · Shanghai Cell Therapy Group Co.,Ltd
Anti-CCR9 CAR T Cells for T Cell Leukaemia/Lymphoma Phase 1 · University College, London
A Study of MEHD7945A and Cobimetinib in Patients With Locally Advanced or Metastatic Cancers With Mutant KRAS Phase 1 · Genentech, Inc.
Pharmacokinetic, Safety, and Efficacy Effects of Oral LBH589 on Dextromethorphan in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer or Malignant Pleural Mesothelioma Phase 1 · Novartis Pharmaceuticals
18F-AraG PET/CT as a Non-Invasive Imaging Biomarker for Chemoradiation Treatment Response in Esophageal Cancer Phase 1 · M.D. Anderson Cancer Center
Nuclear and Near-Infrared (NIR) Imaging in Melanoma Phase 1 · M.D. Anderson Cancer Center
Effect of Tusamitamab Ravtansine on QTc Interval in Participants With Metastatic Solid Tumors Phase 1 · Sanofi
Pharmacokinetic (PK) Study of QL1203 and Vectibix® for the Treatment of RAS Wild-type Metastatic Colorectal Cancer Phase 1 · Qilu Pharmaceutical Co., Ltd.
Aldesleukin With Nivolumab and Standard Chemotherapy for Treatment of Gastric Cancer With Peritoneal Metastasis Phase 1 · Mayo Clinic
A Trial of Y101D, a PD-L1/TGF-β Bispecific Antibody, in Patients With Metastatic or Locally Advanced Solid Tumors Phase 1 · Wuhan YZY Biopharma Co., Ltd.
Dose Escalation Study of Oral Treatment With BIBW 2992 in Patients With Advanced Solid Tumors Phase 1 · Boehringer Ingelheim
HM2023-05: GTB-3650 Trike for High Risk MDS and R/R AML Phase 1 · Masonic Cancer Center, University of Minnesota
A Study to Evaluate the Tolerance and Pharmacokinetics of TQB3602 Capsule Phase 1 · Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Study of Recombinant Human Anti-PD-1 Monoclonal Antibody for Patients With Advanced Solid Tumors Phase 1 · Guangzhou Gloria Biosciences Co., Ltd.
Dose-Escalation Trial of Carfilzomib With and Without Romidepsin in Cutaneous T-Cell Lymphoma Phase 1 · Northwestern University
Tremelimumab + Durvalumab(MEDI4736)+ Belinostat in Urothelial Carcinoma Phase 1 · University of Utah
A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies Phase 1 · Nurix Therapeutics, Inc.
Study of Safety and Efficacy of DKY709 Alone or in Combination With PDR001 in Patients With Advanced Solid Tumors. Phase 1 · Novartis Pharmaceuticals
A Dose Escalation Study of OMP-52M51 in Subjects With Lymphoid Malignancies Phase 1 · OncoMed Pharmaceuticals, Inc.
First in Human Study of CDR404 in HLA-A*02:01 Participants With MAGE-A4 Expressing Solid Tumors Phase 1 · CDR-Life AG

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Trial data from ClinicalTrials.gov (U.S. public domain) and ISRCTN (CC BY 4.0), used with attribution. TrialLens is an independent index, not affiliated with or endorsed by ClinicalTrials.gov, the NIH, or any trial sponsor. For research only — not medical advice.